解读生命密码——人类基因组计划
TOWARDS UNDERSTANDING LIFE’S SECRET——THE HUMAN GENOME PROJECT
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摘要: DNA测序技术的自动化使得人类基因组测序工作在启动10年后就已接近完成.从物理学的角度来看,生物体是工作在单分子水平上的多层次综合的信息、能量和物质加工转换系统.关于生物生长发育和遗传的信息记录在线型分子——核酸的碱基序列中.每个基因是编码一个蛋白质的核酸片段.这些蛋白质分子是分子机器的主要零部件.首次人类基因组测序的完成,只是生命密码破译的开始,而不是结束.年轻的物理学家应积极地参与揭示生命本质的活动.Abstract: Since the automation of DNA sequencing technology,after about a decade the Human Genome Project is going to be fulfilled within the next year.From a physical point of view,an organism is an assembly of multiple levels of information,energy and material transformation systems working on the single molecule level.Information about the organism's development and heredity is encoded in the base sequence of linear molecules:nucleic acids.Each gene is a piece of nucleic acids encoding a protein,which is the main type of component of molecular machines.The complete sequencing of human genome signals the beginning,not the end of the road towards decoding life's secret.Yong physicists should actively participate in exploring the nature of life.
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