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用同步复极化终止心脏中的螺旋波和时空混沌*
Terminating spiral waves and spatiotemporal chaos in heart by synchronous repolarization*
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摘要: 为了模拟电击除颤导致动作电位持续时间缩短，在 Luo-Rudy 相 I 心脏模型中引入了同步复极化。研究了同步复极化对螺旋波和时空混沌动力学的影响。数值结果表明：在控制周期比较小的情况下，同步复极化可以有效消除螺旋波和时空混沌，在有一些控制参数下，同步复极化只能消除螺旋波，或者只能消除时空混沌。当螺旋波不被控制时，观察到螺旋波转变为长周期和长波长的螺旋波或破碎成时空混沌的现象。并对控制机制进行了分析。Abstract: In order to simulate the phenomenon that electric shock defibrillation shortens action potential duration, the synchronous repo-larization process is introduced into Luo-Rudy phase I model of cardiac tissue. Effects of synchronous repolarization on dynamics of spiral waves and spatiotemporal chaos are investigated. Numerical results show that when the control period is small, the synchronous repolarization can effectively eliminate spiral waves and spatiotemporal chaos. However, the synchronous repolarization can only eliminate spiral waves or spatiotemporal chaos under some control parameters. When spiral waves cannot be controlled, the transition from spiral wave to spatiotemporal chaos or the spiral wave with longer period and wavelength is observed. The control mechanism is analyzed.
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