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带电多孔二氧化硅纳米颗粒在硫醇/磷脂混合双层膜上的非特异性吸附*
Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers
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摘要: 制备了表面带阴/阳离子的多孔二氧化硅纳米颗粒，通过QCM-D研究了颗粒在不同pH值环境下与磷脂膜的非特异性吸附情况。结果表明， NH2-MSN在4-8的pH值范围内与磷脂膜相互吸引，而COOH-MSN由于与磷脂膜的电性始终保持一致而无法发生吸附现象。本研究能够帮助理解和预测纳米颗粒与细胞膜间的相互作用，为药物输运提供载体，有助于多孔二氧化硅纳米颗粒在药物输运体系中的应用。
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关键词:
- 多孔二氧化硅纳米颗粒 /
- 磷脂膜 /
- 非特异性吸附 /
- QCM-D
Abstract: Mesoporous silica nanoparticles (MSN) with cationic and anionic surface charges were synthesized, Their adsorption behaviors to the supported lipid membranes at different pH values were also studied using QCM-D. We found that NH2-MSN could be adsorbed onto the membrane at pH values from 4 to 8, while the adsorption of COOH-MSN onto the membrane could not occur due to its charge being always the same as that of the membrane at any pH values. These results might provide the information for understanding and predicting the interactions between nanoparticles and cell membranes, and could be effectively used in drug delivery systems and disease treatment. -
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