摘要:
利用25 MeV/u 40Ar+Se中能重离子核反应,制备包含24种元素在内的多重示踪剂,通过对元素γ谱的分析,研究了正常鼠和肿瘤鼠体内微量元素的分布及代谢.Mg, Sr, Ga, As, Sc, V, Cr, Mo, Co, Fe, Y, Zr, Nb和Ru等元素在肿瘤鼠的粪便和尿液中的排泄时间与正常鼠不同. 肿瘤鼠与正常鼠相比,Na, Mn, Fe和Co的排泄变化较大, 肿瘤鼠的排泄率较正常鼠高;而Ca, Y, Zr和Mo的排泄率肿瘤鼠则较正常鼠低;在正常鼠脏器、组织和血液样品中测出了Na, Rb, Ga, Sc, As, Zn, V, Cr, Mn, Co, Fe、Y, Zr, Tc, Ru, Ag和In等17种元素,肿瘤鼠检测出了除Zn和As之外的其它15种元素. 几乎所有的元素在正常鼠中的吸收均比肿瘤鼠高. 大部分元素分布在肝、肾和毛皮以及实体瘤中, 而Fe和Na在肿瘤组织则没有检测到.
关键词:
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多重示踪剂
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微量元素
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代谢
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肿瘤鼠
Abstract:
A radioactive multitracer solution of the 24 elements, e.g. Be, Na, K, Rb, Mg, Ca, Sr, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Mo, Nb, Tc, Ru, Ag and In, was obtained from the nuclear reaction of 25 MeV/u 40Ar+Se with a series of chemical process. The multitracer solution was orally administered to normal and muscular tumour-bearing mice of male Balb/c mice. Urine and faeces samples of mice were collected. The two group mice were sacrificed after 96 h. The uptake of 17 elements, Na, Rb, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in normal mice while 15 elements, Na, Rb, Ga, Sc, V, Cr, Mn, Co, Fe, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in tumour-bearing mice. Our results indicate that the majority of the detected elements were distributed in liver, kidney, pelt, tumour while a small fraction of the biotrace elements were distributed in heart and spleen (tumour-bearing mice) in the two groups of mice. The higher concentrations of Fe, Na, Mn were detected in heart or kidney of normal mice. Na, Mn, Fe and Co showed better absorption in most tissues in the normal mice, except for Na and Mn in heart.
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