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通关藤中甾体化合物的电喷雾质谱裂解规律研究

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廖辉, 单晓庆, 王林, 王博, 伏劲松, 王晓玲. 2010: 通关藤中甾体化合物的电喷雾质谱裂解规律研究, 质谱学报, 31(2): 103-109.
引用本文: 廖辉, 单晓庆, 王林, 王博, 伏劲松, 王晓玲. 2010: 通关藤中甾体化合物的电喷雾质谱裂解规律研究, 质谱学报, 31(2): 103-109.
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LIAO Hui, SHAN Xiao-qing, WANG Lin, WANG Bo, FU Jin-song, WANG Xiao-ling. 2010: Fragmentation Pathways of Steroids from the Stems of Marsdenia tenacissima by ESI-MS/MS, Journal of Chinese Mass Spectrometry Society, 31(2): 103-109.
Citation: LIAO Hui, SHAN Xiao-qing, WANG Lin, WANG Bo, FU Jin-song, WANG Xiao-ling. 2010: Fragmentation Pathways of Steroids from the Stems of Marsdenia tenacissima by ESI-MS/MS, Journal of Chinese Mass Spectrometry Society, 31(2): 103-109.
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通关藤中甾体化合物的电喷雾质谱裂解规律研究

  • 西南民族大学少数民族药物研究所,四川,成都,610041

Fragmentation Pathways of Steroids from the Stems of Marsdenia tenacissima by ESI-MS/MS

  • 摘要: 利用电喷雾串联质谱(ESI-MS~n)研究从云南产通关藤(Marsdenia tenacissima (Roxb.) Wight et Arn)中分离纯化得到的19种甾体化合物的裂解规律,分析了它们从分子离子出发的多级质谱的裂解碎片,主要报道了tenacigenoside B,tenacigenoside G,tenacigenoside H在ESI正离子模式下[M+Na]~+的裂解途径和碎片离子峰,结合其他16种化合物的裂解实验,说明这些甾体化合物主要丢失C-11和C-12位上的取代基,其次是糖苷上糖顺序断裂.这有助于依据此类化合物结构特点和裂解规律来推断其结构,为此类化合物的快速鉴定提供依据.
    Abstract: Total of 19 steroids fragmentation pathways were investigated by electrospray ionization tandem mass spectrometry(ESI-MS~n) .Those steroids were isolated from the stems of Marsdenia tenacissima, which collected from Yun Nan province. And the fragmentation pathways of tenacigenoside G,tenacigenoside B,tenacigenoside H were summarized detailly in positive mode[M+Na]~+. Combining with the experiment of other 16 compounds, the data reveals the first loss position is C-11 and C-12, then glycosides of C-3 lose orderly. This helps deduce the structures of those compounds according their structural characteristics and loss fragmentations. It also provides the basis for rapid identification of such compounds.
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  • 刊出日期:  2010-04-28

通关藤中甾体化合物的电喷雾质谱裂解规律研究

  • 西南民族大学少数民族药物研究所,四川,成都,610041

摘要: 利用电喷雾串联质谱(ESI-MS~n)研究从云南产通关藤(Marsdenia tenacissima (Roxb.) Wight et Arn)中分离纯化得到的19种甾体化合物的裂解规律,分析了它们从分子离子出发的多级质谱的裂解碎片,主要报道了tenacigenoside B,tenacigenoside G,tenacigenoside H在ESI正离子模式下[M+Na]~+的裂解途径和碎片离子峰,结合其他16种化合物的裂解实验,说明这些甾体化合物主要丢失C-11和C-12位上的取代基,其次是糖苷上糖顺序断裂.这有助于依据此类化合物结构特点和裂解规律来推断其结构,为此类化合物的快速鉴定提供依据.

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