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利用短期心脏记忆消除螺旋波和时空混沌
Eliminate spiral wave and spatiotemporal chaos by using short-term cardiac memory
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摘要: 在Luo—Rudy的心脏模型中引入了记忆效应，该记忆效应表现为膜间电压的延迟耦合．研究了记忆效应对螺旋波的影响，数值模拟结果表明：心脏记忆可导致螺旋波无规则漫游；当延迟时间适当选取时，增加记忆强度会导致螺旋波的频率减小，如果记忆强度超过临界值，心脏记忆效应还可以使螺旋波和时空混沌消失，因为含时外行钾离子电流被心脏记忆过度抑制．Abstract: Cardiac memory effect, which exhibits the time-delayed coupling of membrane voltage, is introduced into Luo-Rudy phase I cardiac model. The effect of the cardiac memory on spiral waves is investigated. The numerical results show that the cardiac memory can lead to irregular meandering of spiral waves. When the delay-time is properly chosen, the increase of memory strength causes the decrease of spiral wave frequency. If memory strength exceeds the critical value, the cardiac memory results in the disappearances of both spiral waves and spatiotemporal chaos in system because the time-dependent potassium ion current is over suppressed by cardiac memory.
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