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Figure 1.  Schematic and representative results of IMC-SR methods

Figure 2.  Evaluation and representative results of IMC-SR-Single models. A Statistical analysis of IMC-SR-Single models trained for MT, ER and Lyso in terms of NRMSE, SSIM and PCC. B Representative results of IMC-SR-Single models trained for MT (green), ER (magenta) and Lyso (yellow). Yellow arrows indicate the false-positive errors of network output images. Scale bar: 3 μm and 1 μm (zoom-in regions)

Figure 3.  Comparisons of IMC-SR-All models and IMC-SR-Single models. A Representative results of the IMC-SR-All model and IMC-SR-Single models trained for CCPs, ER and MTs. Arrows show that the false-positive errors can be reduced considerably with combination loss. Scale bar: 1 μm. B Statistical analysis of the IMC-SR-All model and IMC-SR-Single models trained for ER in terms of NRMSE, SSIM and PCC at different input SNR conditions

Figure 4.  Instant three-color live-cell SR imaging by IMC-SR. A Schematic of IMC-SR-All models applied with temporal continuity (TC). B Comparisons of IMC-SR-All models applied with (lower row) or without (upper row) temporal continuity. C Representative three-color images of MT (green), ER (magenta) and Lyso (yellow) generated by the IMC-SR-All model. Top left: a fraction of the corresponding multichannel-superimposed input image. D Time-lapse three-color images showing a lysosome moving along MTs that continuously contacted the ER and the hitchhiking remodeling mechanism of the ER. Gamma value: 0.8 for MT channel (C and D). Scale Bar: 1 μm (A, B and D), 3 μm (C)