极微型双曲面线性离子阱的模拟研究

何云帆; 朱洪良; 杨卓青; 王艳; 丁桂甫; 孙久文; 魏东亭; 刘民; 姚锦元

doi:10.7538/zpxb.2025.0018

[1]

LI C, CHU S, TAN S, YIN X, JIANG Y, DAI X, GONG X, FANG X, TIAN D. Towards higher sensitivity of mass spectrometry: a perspective from the mass analyzers[J]. Frontiers in Chemistry, 2021, 9: 813359 . doi: 10.3389/fchem.2021.813359

[2]

孙燕, 谢昀, 许秀丽, 谭明乾, 张峰. 高分辨分离分析新技术在食品安全检测领域的应用进展[J]. 色谱, 2023, 41(11): 952 - 959 . doi: 10.3724/SP.J.1123.2023.08026 SUN Yan, XIE Yun, XU Xiuli, TAN Mingqian, ZHANG Feng. Application progress of innovative high resolution separation and analysis technology in food safety detection field[J]. Chinese Journal of Chromatography, 2023, 41(11): 952 - 959 (in Chinese). doi: 10.3724/SP.J.1123.2023.08026

[3]

ZHAI Y, FU X, XU W. Miniature mass spectrometers and their potential for clinical point-of-care analysis[J]. Mass Spectrometry Reviews, 2024, 43(5): 1172 - 1191 . doi: 10.1002/mas.21867

[4]

张兆清, 赵雅平, 王志强, 刘权卫, 侯留东. 磁质谱的发展及应用进展[J]. 化学分析计量, 2022, 31(2): 94 - 100 . doi: 10.3969/j.issn.1008-6145.2022.02.020 ZHANG Zhaoqing, ZHAO Yaping, WANG Zhiqiang, LIU Quanwei, HOU Liudong. Development and application of magnetic mass spectrometry[J]. Chemical Analysis and Meterage, 2022, 31(2): 94 - 100 (in Chinese). doi: 10.3969/j.issn.1008-6145.2022.02.020

[5]

向玉, 侯晨月, 徐伟. 微型化质谱仪研究进展[J]. 生命科学仪器, 2019, 17(3): 28 - 34 . XIANG Yu, HOU Chenyue, XU Wei. Review of mass spectrometry miniaturization[J]. Life Science Instruments, 2019, 17(3): 28 - 34 (in Chinese).

[6]

GAO L, SONG Q, PATTERSON G E, COOKS R G, OUYANG Z. Handheld rectilinear ion trap mass spectrometer[J]. Analytical Chemistry, 2006, 78(17): 5994 - 6002 . doi: 10.1021/ac061144k

[7]

REN Z, GUO M, CHENG Y, WANG Y, SUN W, ZHANG H, DONG M, LI G. A review of the development and application of space miniature mass spectrometers[J]. Vacuum, 2018, 155: 108 - 117 . doi: 10.1016/j.vacuum.2018.05.048

[8]

GUO C L, CHENG Y Q, LIU M K, ZHAO B, ZHANG S W, ZHANG L. Development of the portable mass spectrometer and its application in environmental monitoring[J]. E3S Web of Conferences, 2019, 118: 03055 . doi: 10.1051/e3sconf/201911803055

[9]

MIELCZAREK P, SILBERRING J, SMOLUCH M. Miniaturization in mass spectrometry[J]. Mass Spectrometry Reviews, 2020, 39(5/6): 453 - 470 .

[10]

WANG J, PURSELL M E, DeVOR A, AWOYEMI O, VALENTINE S J, LI P. Portable mass spectrometry system: instrumentation, applications, and path to omics analysis[J]. Proteomics, 2022, 22(23/24): e2200112.

[11]

陈振宇, 杨宝坤, 姜婷, 徐伟. 便携VOCs质谱仪系统设计与性能优化[J]. 质谱学报, 2024, 45(5): 609 - 615 . CHEN Zhenyu, YANG Baokun, JIANG Ting, XU Wei. Design and performance optimization of a portable VOCs mass spectrometer system[J]. Journal of Chinese Mass Spectrometry Society, 2024, 45(5): 609 - 615 (in Chinese).

[12]

SCHULTZE K P. Advanced system components for the development of a handheld ion trap mass spectrometer[D]. North Carolina, United States: The University of North Carolina at Chapel Hill, 2014.

[13]

JIANG T, ZHANG H, TANG Y, ZHAI Y, XU W, XU H, ZHAO X, LI D, XU W. A “brick mass spectrometer” driven by a sinusoidal frequency scanning technique[J]. Analytical Chemistry, 2017, 89(10): 5578 - 5584 . doi: 10.1021/acs.analchem.7b00719

[14]

SYMS R R A, WRIGHT S. MEMS mass spectrometers: the next wave of miniaturization[J]. Journal of Micromechanics and Microengineering, 2016, 26(2): 023001 . doi: 10.1088/0960-1317/26/2/023001

[15]

李振波, 张琛, 赵小林, 杨春生. 直径1 mm电磁型实用超微马达的设计[J]. 仪器仪表学报, 2000, 21(2): 163 - 166 . doi: 10.3321/j.issn:0254-3087.2000.02.016 LI Zhenbo, ZHANG Chen, ZHAO Xiaolin, YANG Chunsheng. Design of the electromagnetic micro-motor with 1 mm diameter[J]. Chinese Journal of Scientific Instrument, 2000, 21(2): 163 - 166 (in Chinese). doi: 10.3321/j.issn:0254-3087.2000.02.016

[16]

苏宇锋, 陈文元, 崔峰. 电磁驱动柔性振动膜无阀微泵[J]. 微细加工技术, 2003(4): 60 - 64 . SU Yufeng, CHEN Wenyuan, CUI Feng. An electro-magnetically actuated valveless micropump with flexible diaphragm[J]. Microfabrication Technology, 2003(4): 60 - 64 (in Chinese).

[17]

SZYSZKA P, JENDRYKA J, SOBKÓW J, ZYCHLA M, BIAŁAS M, KNAPKIEWICZ P, DZIUBAN J, GRZEBYK T. MEMS quadrupole mass spectrometer[C]//2023 IEEE 36th International Vacuum Nanoelectronics Conference (IVNC). July 10-13, 2023. Cambridge, MA, USA. IEEE, 2023: 195-197.

[18]

GUO Q, GAO L, ZHAI Y, XU W. Recent developments of miniature ion trap mass spectrometers[J]. Chinese Chemical Letters, 2018, 29(11): 1578 - 1584 . doi: 10.1016/j.cclet.2017.12.009

[19]

陈小霞, 任熠, 黄奇, 向大军, 李长伟, 洪义, 李磊, 黄正旭, 李梅, 徐经纬, 周振. 多次反射飞行时间质谱仪高性能矩形离子阱的研制[J]. 分析化学, 2025, 53(1): 38 - 46 . CHEN Xiaoxia, REN Yi, HUANG Qi, XIANG Dajun, LI Changwei, HONG Yi, LI Lei, HUANG Zhengxu, LI Mei, XU Jingwei, ZHOU Zhen. Development of a high-performance rectangular ion trap for multi-reflection time-of-flight mass spectrometer[J]. Chinese Journal of Analytical Chemistry, 2025, 53(1): 38 - 46 (in Chinese).

[20]

van AMEROM F H W, CHAUDHARY A, CARDENAS M, BUMGARNER J, SHORT R T. Microfabrication of cylindrical ion trap mass spectrometer arrays for handheld chemical analyzers[J]. Chemical Engineering Communications, 2007, 195(2): 98 - 114 . doi: 10.1080/00986440701569176

[21]

陈婷, 姚锦元, 蒋公羽, 肖育, 陈新, 杨雨, 郑恒. 基于微机电系统加工技术的微小型矩形离子阱的研制[J]. 质谱学报, 2021, 42(1): 65 - 72 . doi: 10.7538/zpxb.2019.0154 CHEN Ting, YAO Jinyuan, JIANG Gongyu, XIAO Yu, CHEN Xin, YANG Yu, ZHENG Heng. Development of micro-sized rectangular ion trap based on micro-electro-mechanical system processing technology[J]. Journal of Chinese Mass Spectrometry Society, 2021, 42(1): 65 - 72 (in Chinese). doi: 10.7538/zpxb.2019.0154

[22]

ZHANG Q, LU X, CHEN T, XIAO Y, YAO R, YAO J. A miniature four-channel ion trap array based on non-silicon MEMS technology[J]. Micromachines, 2021, 12(7): 831 . doi: 10.3390/mi12070831

[23]

LU X, YEOW J T W, JIANG G, XIAO Y, YAO R, ZHANG Q, SONG J, YAO J. Simulation of a miniature linear ion trap with half-round rod electrodes[J]. Micromachines, 2022, 13(10): 1572 . doi: 10.3390/mi13101572

[24]

GEEAR M, SYMS R R A, WRIGHT S, HOLMES A S. Monolithic MEMS quadrupole mass spectrometers by deep silicon etching[J]. Journal of Microelectromechanical Systems, 2005, 14(5): 1156 - 1166 . doi: 10.1109/JMEMS.2005.851799

[25]

BLAIN M G, RITER L S, CRUZ D, AUSTIN D E, WU G, PLASS W R, COOKS R G. Towards the hand-held mass spectrometer: design considerations, simulation, and fabrication of micrometer-scaled cylindrical ion traps[J]. International Journal of Mass Spectrometry, 2004, 236(1/2/3): 91 - 104 .

[26]

钟蠡, 潘晓斌, 雷天才, 蒋家东. 高精度双曲面线性离子阱加工方法研究[J]. 制造技术与机床, 2019(11): 23 - 25 . ZHONG Li, PAN Xiaobin, LEI Tiancai, JIANG Jiadong. Study on machining method for high-precision linear ion trap with hyperboloidal surface[J]. Manufacturing Technology & Machine Tool, 2019(11): 23 - 25 (in Chinese).

[27]

李佳伟, 吉方, 赵舜. 双曲面型离子阱极杆精密车削方法[J]. 制造技术与机床, 2022(4): 103 - 109 . LI Jiawei, JI Fang, ZHAO Shun. Hyperbolic ion trap rod fabricated using precision turning method[J]. Manufacturing Technology & Machine Tool, 2022(4): 103 - 109 (in Chinese).

[28]

ZHANG Y, WU H, YAO R, QIAN J, GE S, MA Q, BAI H, XIAO Y, LI X. Simulation of unidirectional ion ejection in linear ion traps with asymmetric radiofrequency voltage[J]. Rapid Communications in Mass Spectrometry, 2020, 34(9): e8731. doi: 10.1002/rcm.8731

[29]

贾滨, 杨茂璘, 刘吉星, 赵高升, 黄玉梁, 程平. 质谱相关四极场的设计思路探讨[J]. 质谱学报, 2023, 44(3): 348 - 356 . doi: 10.7538/zpxb.2022.0097 JIA Bin, YANG Maolin, LIU Jixing, ZHAO Gaosheng, HUANG Yuliang, CHENG Ping. Discussion on design ideas of quadrupole field of mass spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2023, 44(3): 348 - 356 (in Chinese). doi: 10.7538/zpxb.2022.0097

[30]

YINON J, KLEIN F. The quadrupole and its applications in vacuum technology and mass spectrometry[J]. Vacuum, 1971, 21(9): 379 - 383 . doi: 10.1016/0042-207X(71)92402-X

[31]

SUDAKOV M, DOUGLAS D J. Linear quadrupoles with added octopole fields[J]. Rapid Communications in Mass Spectrometry, 2003, 17(20): 2290 - 2294 . doi: 10.1002/rcm.1187

[32]

王伟民, 徐锐峰, 江游, 张谛, 徐福兴, 丁传凡. 离子阱中3种软件程序的离子运动轨迹数值模拟对比[J]. 质谱学报, 2022, 43(4): 495 - 503 . doi: 10.7538/zpxb.2021.0180 WANG Weimin, XU Ruifeng, JIANG You, ZHANG Di, XU Fuxing, DING Chuanfan. Comparison of numerical simulation of ion trajectories in three simulation programs of ion trap[J]. Journal of Chinese Mass Spectrometry Society, 2022, 43(4): 495 - 503 (in Chinese). doi: 10.7538/zpxb.2021.0180

[33]

邵辉丽, 潘志兵, 王顺治, 任莉. 线型离子阱中空间电荷效应的理论分析[J]. 原子与分子物理学报, 2019, 36(4): 538 - 540 . doi: 10.3969/j.issn.1000-0364.2019.04.002 SHAO Huili, PAN Zhibing, WANG Shunzhi, REN Li. Theoretical analysis of the space charge effect in linear ion trap[J]. Journal of Atomic and Molecular Physics, 2019, 36(4): 538 - 540 (in Chinese). doi: 10.3969/j.issn.1000-0364.2019.04.002

[34]

LI X, ZHANG X, YAO R, HE Y, ZHU Y, QIAN J. Design and performance evaluation of a linear ion trap mass analyzer featuring half round rod electrodes[J]. Journal of the American Society for Mass Spectrometry, 2015, 26(5): 734 - 740 . doi: 10.1007/s13361-015-1085-2

[35]

MARCH R E. Quadrupole ion traps[J]. Mass Spectrometry Reviews, 2009, 28(6): 961 - 989 . doi: 10.1002/mas.20250

[36]

ZHANG Z, YUAN G, HE Y, QIAN J, ZHANG S, YAO R, DING C, LI X. Research of unidirectional ion ejection in printed-circuit-board ion trap[J]. Chinese Journal of Analytical Chemistry, 2017, 45(2): 297 - 302 . doi: 10.1016/S1872-2040(17)60995-2

[37]

徐福兴, 靳留雨, 钱炳君, 王伟民, 丁传凡. 十二极电场对线性离子阱分析性能的影响[J]. 分析化学, 2021, 49(8): 1282 - 1288 . XU Fuxing, JIN Liuyu, QIAN Bingjun, WANG Weimin, DING Chuanfan. Effect of dodecapole electric field on performance of linear ion trap mass analyzer[J]. Chinese Journal of Analytical Chemistry, 2021, 49(8): 1282 - 1288 (in Chinese).

[38]

姚如娇, 何洋, 肖育, 丁正知, 袁广洲, 张在越, 钱洁, 张曙光, 李晓旭. 三角形电极离子阱的理论模拟及性能优化[J]. 分析化学, 2016, 44(11): 1793 - 1797 . doi: 10.1016/S1872-2040(16)60975-1 YAO Rujiao, HE Yang, XIAO Yu, DING Zhengzhi, YUAN Guangzhou, ZHANG Zaiyue, QIAN Jie, ZHANG Shuguang, LI Xiaoxu. Optimization of linear ion trap mass analyzer with triangular electrodes by simulation[J]. Chinese Journal of Analytical Chemistry, 2016, 44(11): 1793 - 1797 (in Chinese). doi: 10.1016/S1872-2040(16)60975-1

[39]

吴辉, 朱雯飞, 葛赛金, 张英军, 姚如娇, 李晓旭. 非对称双曲面线性离子阱的设计及性能研究[J]. 质谱学报, 2021, 42(6): 1145 - 1155 . WU Hui, ZHU Wenfei, GE Saijin, ZHANG Yingjun, YAO Rujiao, LI Xiaoxu. Design and performance evaluation of asymmetric hyperboloid linear ion trap[J]. Journal of Chinese Mass Spectrometry Society, 2021, 42(6): 1145 - 1155 (in Chinese).