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酵母β-葡聚糖对C离子辐射损伤小鼠免疫系统的防护作用
Protective Effect of Yeast β-glucan on Immune System of Mice Irradiated by Carbon Ions
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摘要: 用12C6-离子束对小鼠进行一次性全身辐照，检测不同剂量的酵母β-葡聚糖对”C6＋辐射损伤小鼠免疫系统的防护作用。辐照后观察小鼠的体重、毛色及行为变化，照后第2天和第7天检测小鼠外周血中白细胞含量，照后第8天检测小鼠胸腺和脾脏内SOD，GSH—PX活性和MDA含量。实验结果表明，给予酵母β-葡聚糖能减缓辐照引起的小鼠体重急剧下降，增加小鼠外周血中白细胞含量，不同程度地恢复胸腺和脾脏SOD和GSH-PX活性，降低胸腺和脾脏MDA含量。表明酵母β-葡聚糖对挖C6＋引起的小鼠辐射损伤具有防护作用。Abstract: Abstract. To detect Yeast β-glucan＇s protective effect on mice~s immune system after C ion beam radia- tion, mice were used as the test model. We observed the weight, hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile, the content of white blood cell, on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD, GSH-PX activity and MDA content of the mice on the 8th day. The results showed that yeast β-gluean could reduce the rapid weight loss of mice, increase white blood cell content, increase thymus and spleen SOD, GSH-PX activi- ty, decrease MDA content of thymus and spleen. These results indicate that yeast 13-glucan can protect mice＇s immune system against C ion beam radiation damage.
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